Advances in Immunoassay Technology, 1st ed. 2012

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Advances in Immunoassay Technology 2012
Norman H. L. Chiu and Theodore K. Christopoulos




This book focuses on some of the latest technologies for the development of new immunoassays.
From the basic in vitro study of a specific biomolecule to the diagnosis or prognosis of a specific disease, one of the most widely used technology is immunoassays. By using a specific antibody to recognize the biomolecule of interest, relatively high specificity can be achieved by immunoassays, such that complex biofluids (e.g. serum, urine, etc.) can be analyzed directly.
In addition to the binding specificity, the other key features of immunoassays include relatively high sensitivity for the detection of antibody-antigen complexes, and a wide dynamic range for quantitation. Over the past decade, the development and applications of immunoassays have continued to grow

Contents
Preface
Part 1 New Materials and Assay Interference
1 Recombinant Antibodies and Non-Antibody Scaffolds for Immunoassays
2 Polyacrylonitrile Fiber as Matrix for Immunodiagnostics
3 Interferences in Immunoassays
Part 2 Label-Free Technologies
4 Fundamentals and Applications of Immunosensors
5 Capabilities of Piezoelectric Immunosensors for Detecting Infections and for Early Clinical Diagnostics
6 Label-Free Detection of Botulinum Neurotoxins Using a Surface Plasmon Resonance Biosensor
7 Immunoassays Using Artificial Nanopores
Part 3 Multiplexing Technologies
8 Multiplexed Immunoassays
9 Multiplexed Bead Immunoassays: Advantages and Limitations in Pediatrics





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