Understanding Tuberculosis: Global Experiences and Innovative Approaches to the Diagnosis, 2012

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Understanding Tuberculosis: Global Experiences and Innovative Approaches to the Diagnosis
Pere-Joan Cardona
ISBN: 9533079387




This book presents the experience of worldwide specialists on the tuberculosis diagnosis, along with its lights and shadows.

Mycobacterium tuberculosis is a disease that is transmitted through aerosol. This is the reason why it is estimated that a third of humankind is already infected by Mycobacterium tuberculosis. The vast majority of the infected do not know about their status. Mycobacterium tuberculosis is a silent pathogen, causing no symptomatology at all during the infection. In addition, infected people cannot cause further infections. Unfortunately, an estimated 10 per cent of the infected population has the probability to develop the disease, making it very difficult to eradicate. Once in this stage, the bacilli can be transmitted to other persons and the development of clinical symptoms is very progressive.
Therefore the diagnosis, especially the discrimination between infection and disease, is a real challenge.

Contents
Part 1 Experience on Laboratory diagnosis around the World
1 Clinical Laboratory Diagnostics for Mycobacterium tuberculosis
2 Laboratory Diagnosis of Latent and Active Tuberculosis Infections in Trinidad a Tobago and Determination of Drug Susceptibility Profile of Tuberculosis Isolates in the Caribbean
3 Tuberculosis is Still a Major Challenge in Africa
4 Tuberculosis in Saudi Arabia
5 Diagnosis of Mycobacterium tuberculosis
6 Diagnosis of Smear-Negative Pulmonary Tuberculosis in Low-Income Countries: Current Evidence in Sub-Saharan Africa with Special Focus on HIV Infection or AIDS
7 Immunologic Diagnosis of Neurotuberculosis
8 Diagnostic Methods for Mycobacterium tuberculosis and Challenges in Its Detection in India
9 Management of TB in HIV Subjects, the Experience in Thailand
10 Mycobacterium tuberculosis: Biorisk, Biosafety and Biocontainment
Part 2 New approaches to the TB diagnosis
11 New Diagnostics for Mycobacterium tuberculosis
12 Nanodiagnostics for Tuberculosis
13 Sputum Smear Microscopy for Tuberculosis: Evaluation of Autofocus Functions and Automatic Identification of Tuberculosis Mycobacterium
14 The Use of Phage for Detection, Antibiotic Sensitivity Testing and Enumeration
15 Molecular Imaging in TB: From the Bench to the Clinic
16 Data Mining Techniques in the Diagnosis of Tuberculosis
17 Immunological Diagnosis of Active and Latent TB
18 Immune Diagnosis of Tuberculosis Through Novel Technologies
19 Exosomes: New Tuberculosis Bio markers - Prospects From the Bench to the Clinic
20 Molecular Techniques for Identification of Species of the Mycobacterium tuberculosis Complex: The use of Multiplex PCR and an Adapted HPLC Method for Identification of Mycobacterium bovis and Diagnosis of Bovine Tuberculosis
Part 3 Improving detection and control of resistances
21 Survey and Molecular Characterization of Drug- Resistant M. tuberculosis Clinical Isolates from Zunyi, Guizhou Province of China
22 Molecular Biological Techniques for Detection of Multidrug Resistant Tuberculosis (MDR) and Extremely Drug Resistant Tuberculosis (XDR) in Clinical Isolates of Mycobacterium tuberculosis
23 Detection of Mycobacterium tuberculosis and Drug Resistance: Opportunies and Challenges in Morocco
24 Pattern of Circulating Mycobacterium tuberculosis Strains in Sri Lanka
25 Health Interventions to Improve the Medication Efficacy in Tuberculosis Treatment







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